Hello,

I am trying to extract all human SNPs with big indels in a batch. I  
am interested in the sequences with and without the indels plus the  
flanking regions.  I want to get for each snp an alignment similar to  
that appear in each snp page.

I took a look here http://www.soe.ucsc.edu/pipermail/genome/2007- 
January/012650.html
but I have few  questions:

(a) Here is the approach I start with. I try to treat the insertion/  
deletions/in-del in snp128 separately. First I get the sequence and  
its flanking in the reference genome and then I delete/insert the  
bases in the right places according to the snp table.
Is there a better way to get both sequences for each snp (the  
reference and the snp) in a batch?

(b) Is the information about which variant is the ancestral one  
available somewhere?

Thanks

Einat


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