Hi Luvina,

On 1/20/11 7:24 PM, Luvina Guruvadoo wrote:
> Hello Duke,
>
> My apologies for not clarifying in my previous email. When zoomed in 
> to base level, the mismatching bases appear white. When zoomed out, 
> the positions of the mismatching bases are represented by a thin red 
> line.
>

Thanks. I also recognized this point.

> As for the screenshot you provided, is it possible that the alignment 
> was made to a different assembly (not hg19)? If so, this may be why 
> you are seeing more than two mismatches per read.

I dont really understand this point. The data I work with is mouse 
(mm9), and it was aligned with bowtie with reference mm9. Did you mean 
if a data aligned to one species will be shown like that if uploaded to 
different species?

> If not, I suggest you try to troubleshoot your BOWTIE pipeline.

Anyway, I think there might be something with our bowtie pipeline. We 
will have to carefully check it.

Thanks,

D.
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