Dear Vish,

To get to the DNA sequence for the hg18 assembly you will need to select the 
hg18 assembly from the gateway page: http://genome.ucsc.edu/cgi-bin/hgGateway

After clicking "submit", click on "DNA" from the blue navigation bar.

For each assembly that you are interested in getting DNA sequences, you will 
need to go through this process.


Unfortunately, the get DNA tool doesn't have the ability to separate out the 
different classes of repeats. However, there is a way to get the sequence for 
low complexity repeats using the Table Browser. To get to the Table Browser 
click on "Tables" from the blue navigation bar.

Set the following:

Select the clade, genome, and assembly that you are interested in.
group: Variations and Repeats
track: RepeatMasker  
table: rmsk 
region: genome
filter: click on "create". After "repClass does", paste in: 'Low_complexity' 
(to get this value click on "describe table schema" on the main table browser 
page for the table you are interested in.) Click "submit".
output format: sequence

click "get output"
click "get sequence"

This will give you the sequences of all of the low complexity repeats.

Please feel free to contact the mailing list if you have further questions.

Vanessa Kirkup Swing
UCSC Genome Bioinformatics Group

----- Original Message -----
From: "Vishnu Mishra" <[email protected]>
To: [email protected]
Sent: Thursday, February 10, 2011 2:32:22 PM
Subject: [Genome] Low complexity sequence

The Get DNA in window function allows for identifying repeats by lower case or 
Ns. Is there a way to do the same for low complexity sequence filtering? Can 
they be highlighted or is there some other program to identify low complexity 
sequence?

Also, the get DNA in window defaults to hg19. Is there a way to get DNA 
sequence for hg18.

Thanks

Vish

Vishnu Mishra
Senior Scientist, Diagnostic Assay Development
Illumina, Inc.
9885 Towne Centre Drive
San Diego, CA 92121
Tel: 858-246-8813
E-mail: [email protected]<mailto:[email protected]>

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