Hi, my name is James Jacobs and I'm a Heme/Onc Fellow at Children's Hospital & Research Center at Oakland. I'm currently doing research that involves C57Bl/6J mice. I'm relatively new to the UCSC Genome Browser and I have a question about the July 2007 assembly
The assembly notes state that it is from the C57BL/6J strain. In my reading of the liturature, I have noted that the C57Bl/6J mice have the "single" genotype at their hemoglobin beta chain (there are different genotypes such as "single" and diffuse" depending on the strain of mouse). In the Genome Browser at position Chr7:110,961,038-110,962,437 there is a hemoglobin beta chain that is marked as Hbb-b1 and in the descriptive notes it is called the hemoglobin D major chain. At position Chr7:110,975,048-110,976,441 there is another hemoglobin beta chain that is also marked as Hbb-b1. In the descriptive notes, this is also labeled as hemoglobin D major chain. I'm confused because the C57Bl/6J mice are not suppose to have hemoglobin D. They are suppose to have hemoglobin S (single). Do you have any insight into this? I'm trying to clarify these results before I go on to the next phase of my experiment. Any help you might be able to offer would be greatly appreciated. Thanks so much for your time, James E. Jacobs MD, MPH CONFIDENTIALITY NOTICE: This electronic message (and any attachments) is intended to be for the use only of the named recipient, and may contain information that is confidential or privileged. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution or use of the contents of this message is strictly prohibited. If you have received this message in error or are not the named recipient, please notify us immediately by contacting the sender at the electronic mail address noted above, and delete and destroy all copies of this message (and any attachments). Thank you. _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
