Hi Thomas,

you can try the suggestions from here:
http://biostar.stackexchange.com/questions/6107/anyone-know-a-general-variant-snp-indel-effect-predictor-annotator
<http://biostar.stackexchange.com/questions/6107/anyone-know-a-general-variant-snp-indel-effect-predictor-annotator>or
here
http://biostar.stackexchange.com/questions/5495/predicted-impact-of-indels
or here
http://biostar.stackexchange.com/questions/2155/how-to-check-if-the-iupac-snp-code-changes-translation

good luck!

cheers
Max



On Tue, Apr 12, 2011 at 5:09 PM, Thomas Juettemann <[email protected]>wrote:

> Hi all,
>
> I was wondering if anyone knows a program (web-service or stand alone)
> that returns if a given sequence variation  has an effect on the gene
> product (e.g. frameshift, introduction of a stop codon).
> Ideally I'd like to submit a list of variations (in BED format), the
> reference genome (hg18/19) and get type of effect back.
>
> Thanks,
> Thomas
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