Hi, I have a concern about the validation by ENCODE and REFSEQ of the gene:
TMSL3 chr4:91,759,560-91,760,450 It appears to be a processed pseudogene of the highly expressed TMSB4X Am I correct in assuming its validation depends on three mRNA sequences which on the UCSC browser mRNA information page elicit a warning about sequence correction to pseudogenes? - e.g. http://genome.ucsc.edu/cgi-bin/hgchgsid=193876573&o=91759642&t=91760216&g=mrna&i=CR605307 The ESTs which align with TMSL3 appear at least equally, if not more likely to be transcripts from TMSB4X. I'm not clear why they appear aligned against chr4 Does this perhaps reflect failure of some pipeline step to detect the short (11 aa) exon 3, therefore signalling a longer match to the pseudogene? John Edwards _______________________________________________ Genome maillist - [email protected] https://lists.soe.ucsc.edu/mailman/listinfo/genome
