Good Morning John:

Can you provide a URL to the NCBI nt database fasta file ?
I would guess it has quite a few individual sequences in the single file.
You could certainly work around this situation and most likely get
the job done faster by breaking up the fasta file into smaller chunks
and run them in parallel on a cluster system.

--Hiram

>> Does this suggest an error in the output functions? We're also wondering 
>> if the size of nt.fa (36GB) is just too large for blat. Any other ideas 
>> on what might be causing the segfault? We've had success with smaller 
>> databases.
>>
>> Thanks
>>
>> John
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