Dear UCSC  Genomics,

I've been trying to convert a ~195MB fixedStep wig file to bigwig, using 
wigToBigWig, but keep coming up with this error: 'There's more than one value 
for chr1 base 40730 (in coordinates that start with 1).'

For my fixedStep files, I'm using the following header: fixedStep chrom=chr1 
start=10010 step=30 span=300. The data is continuous for each chromosome, ie 
every step along the chromosome has a score of >= 0, without exceeding the 
length of the chromosome.

When I load the data for a single chromosome, or a group of chromosomes in wig 
format directly to the UCSC browser, the data is displayed correctly, and 
matches my pile-up track perfectly.

When I try to convert a single chromosome wig file to bigWig, I get the same 
error. When I look at my data around the base position that is called as being 
in error, it is typically in an area with scores of many 0's either side, but 
seems to me otherwise unremarkable. It isn't occurring near a fixedStep title 
line.

I've tried adjusting my bin sizes and span sizes, my start positions etc, but 
to no avail.

I don't fully understand exactly what the error means, which makes it much more 
difficult to fix! If anyone could explain what causes this type of error, I 
would be very grateful!


Thanks in advance,

Michael McCarthy,
Wellcome Trust Centre for Cellular and  Molecular Physiology,
University of Oxford,
UK


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