Hi Peter,

One of our engineers mentioned the BED 4-6 option was added to the 
multiple option because this was requested by ENCODE users. However for 
BED12, he says "[looking at the code] if the range find on the chain 
returns two or more top-scoring chains of the same score, it calls it 
"duplicated-in-new" and returns without outputting anything else. In 
theory this could be relaxed so that multiple qualifying chains would be 
output. Obviously, it might be harder for the user to analyze the 
results if there are many chains. I suppose a different way would be to 
let the user choose the topN high-scoring chains as a way to deal with 
regions with many hundreds or thousands of hits."

Please contact us again at [email protected] if you have any further 
questions.

---
Luvina Guruvadoo
UCSC Genome Bioinformatics Group


On 11/17/2011 6:34 AM, Peter Ebert wrote:
> Hi,
> liftOver informed me that, when using the -multiple option, it can only use
> files in BED4/5/6 format as input. Is that a technical (= programming related)
> limitation or is there a more complicated explanation? It would be nice if
> someone could elaborate on that issue.
> Thanks in advance.
> Cheers,
> Peter
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