Here's a series of eclass changes I've been working on since August to allow Python modules to be cross-compiled. We previously believed this to be practically impossible without significant changes upstream and in the wider Python ecosystem so getting here feels like quite an achievement. While the approach is a little unconventional, it doesn't feel overly hacky and the results are quite consistently good.
These changes should also benefit prefix and I did a full prefix bootstrap for the first time this week just to make sure I didn't break it. A handful of other Python packages that don't quite follow the usual mantra have needed fixing up. I haven't included those changes here but you can view them on this GitHub pull request. https://github.com/gentoo/gentoo/pull/9822 Once this is in place, I can finish my long-awaited revamp of my cross-boss project that will allow you to cross-compile @system from scratch with very little effort.