i generally kill knotify and kded when they misbehave and haven't encountered any noticeable problems after doing so. I hate it when i forget to check for these two before starting an overnight portage update.
also heres a blog post related to the kded problem i seen on planet kde recently. http://kdepepo.wordpress.com/2011/05/11/troubleshooting-kded4-bugs/ -- - Yohan Pereira "A man can do as he will, but not will as he will" - Schopenhauer