Esta info es oficial del sitio de Mediawiki. Creo que es el punto 0 de donde tendriamos que partir.

     MediaWiki is slow, how can I make it faster?

   * First you should try installing a free PHP cache engine such as
     eAccelerator <http://eaccelerator.net/> or APC
     <http://pecl.php.net/package/APC> (after installing, modify your
     $wgMainCacheType
     <http://www.mediawiki.org/wiki/Manual:$wgMainCacheType>
     accordingly). The engine will save the parsed PHP scripts and
     enhance performance a lot (this is something you should use anyway
     on any PHP installation with non-trivial traffic). Proprietary
     Zend Platform <http://www.zend.com/store/products/zend-platform/>
     also contains a bytecode cache, however its "dynamic content
     caching" is not supported in MediaWiki at the current time.
   * Use Squid <http://meta.wikimedia.org/wiki/Squid> or MediaWiki's
     native file cache
     <http://www.mediawiki.org/wiki/Manual:File_cache> ($wgUseFileCache
     <http://www.mediawiki.org/wiki/Manual:$wgUseFileCache> = true) to
     cache whole pages
   * Memcached <http://meta.wikimedia.org/wiki/Memcached> will provide
     some performance benefit, especially for heavily viewed sites. See
     also the cache
     <http://www.mediawiki.org/wiki/Help:Configuration_settings#Cache>
     section of the configuration settings.
   * See the Reduction
     <http://www.mediawiki.org/wiki/Help:Configuration_settings#Reduction>
     section of the configuration setting.
   * See the $wgUseDatabaseMessages
     <http://www.mediawiki.org/wiki/Manual:$wgUseDatabaseMessages> setting.
   * Switching the MySQL table type to MyISAM may be faster for
     single-user wikis on lower-end computers. See also: MySQL Storage
     Comparison
     <http://dev.mysql.com/tech-resources/articles/storage-engine/part_3.html>.
   * Disable ImageMagick in LocalSettings.php $wgUseImageMagick
     <http://www.mediawiki.org/wiki/Manual:$wgUseImageMagick>, though
     this will cause reduced thumbnail quality. ImageMagick imposes a
     performance penalty during various page views and edits and can
     slow down bulk uploads.
   * For a heavy concurrent write load, InnoDB is essential. Set
     $wgAntiLockFlags
     <http://www.mediawiki.org/wiki/Manual:$wgAntiLockFlags> =
     ALF_NO_LINK_LOCK | ALF_NO_BLOCK_LOCK to reduce lock contention, at
     the expense of introducing occasional inconsistencies. Use
     memcached not the default MySQL-based object cache.
   * If using Squid, enable HTCP <http://en.wikipedia.org/wiki/HTCP>
     and add $wgHTCPMulticastAddress
     <http://www.mediawiki.org/wiki/Manual:$wgHTCPMulticastAddress>
   * If you have $wgReadOnly
     <http://www.mediawiki.org/wiki/Manual:$wgReadOnly> set, check bug
     11533 <http://bugzilla.wikimedia.org/show_bug.cgi?id=11533>.


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