You should always use the "gro file" generated by pdb2gmx or the "equal" pdb 
file (same topology and nomenclature but different format). Because not only 
the nomenclature could be deferent between your original pdb file and the top 
file, but also the number and indexing of atoms may also be deferent. I think 
the waring is aware you that it's encountered topology mismatch.


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