Pradip Biswas wrote:
Dear All,
All the estrogen receptor alpha structure that I found on PDB
repository, contain mainly the ligand binding domain (residues 301-550).
I am looking for a structure that has the hinge region (240-300) as
well. Does anyone have any extended structure (even if it is an
engineered one) of Estrogen Receptor Alpha which contains the ligand
binding domain plus the hinge region residues: 240-550 ??
Ligand binding domains can be disordered, which makes them unsuited for
X-ray or NMR structure determination. Thus they might be missing from
the results or indeed excised before structure determination. Read the
comments in the PDB files and/or literature to see.
Mark
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