Journals with 90% rejection rates, like Nature, Science and Cell have
considerably higher editorial costs (per published paper) than those with
rejection rates of 40%-60%, which is an average value for middle-of-the-road
biomedical journals. Nearly the same effort goes into peer reviewing a
rejected paper as an accepted paper.

As PLoS charges only those authors whose papers are published, and as they
aspire to Nature-like selectivity, their editorial costs will be higher than
"average" open-access journals. You might even call their $1,500 a bargain.

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Alexander M. Grimwade Ph. D.
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