I installed setuptools on my Macbook Pro Mountain Lion, and Babel with 
Jinja2 in order to run Babel locally.

$ sh setuptools-0.6c11-py2.7.egg --prefix=~ 
--install-dir=/Library/Python/2.7/site-packages/
$ easy_install babel jinja2

After install those packages, I have this warning per any request:

WARNING  2012-08-03 20:56:32,586 py_zipimport.py:139] Can't open zipfile 
/Library/Python/2.7/site-packages/setuptools-0.6c11-py2.7.egg: IOError: 
[Errno 13] file not accessible: 
'/Library/Python/2.7/site-packages/setuptools-0.6c11-py2.7.egg'


But after 2 minutes with any request I have this error and I have to 
restart the application

INFO     2012-08-03 21:00:50,713 py_zipimport.py:148] 
zipimporter('/Library/Python/2.7/site-packages/setuptools-0.6c11-py2.7.egg', 
'')
ERROR    2012-08-03 21:00:51,061 wsgi.py:189] 
Traceback (most recent call last):
  File 
"/Applications/GoogleAppEngineLauncher.app/Contents/Resources/GoogleAppEngine-default.bundle/Contents/Resources/google_appengine/google/appengine/runtime/wsgi.py",
 
line 187, in Handle
    handler = _config_handle.add_wsgi_middleware(self._LoadHandler())
  File 
"/Applications/GoogleAppEngineLauncher.app/Contents/Resources/GoogleAppEngine-default.bundle/Contents/Resources/google_appengine/google/appengine/runtime/wsgi.py",
 
line 225, in _LoadHandler
    handler = __import__(path[0])
  File 
"/Applications/GoogleAppEngineLauncher.app/Contents/Resources/GoogleAppEngine-default.bundle/Contents/Resources/google_appengine/google/appengine/tools/dev_appserver_import_hook.py",
 
line 676, in Decorate
    return func(self, *args, **kwargs)
  File 
"/Applications/GoogleAppEngineLauncher.app/Contents/Resources/GoogleAppEngine-default.bundle/Contents/Resources/google_appengine/google/appengine/tools/dev_appserver_import_hook.py",
 
line 1858, in load_module
...
  File 
"/Applications/GoogleAppEngineLauncher.app/Contents/Resources/GoogleAppEngine-default.bundle/Contents/Resources/google_appengine/google/appengine/tools/dev_appserver_import_hook.py",
 
line 592, in __init__
    raise IOError(errno.EACCES, 'file not accessible', filename)
IOError: [Errno 13] file not accessible: 
'/Library/Python/2.7/site-packages/setuptools-0.6c11-py2.7.egg'
INFO     2012-08-03 21:01:11,506 dev_appserver.py:2952] "GET / HTTP/1.0" 
500 -

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