Regarding your concerns about keeping your data reliable, here 
<https://cloud.google.com/sql/sla>, you may take a look at Google Cloud SQL 
SLA which says the Covered Service (including Cloud SQL) will provide a 
Monthly Uptime Percentage to Customer of at least 99.95%. Furthermore, you 
can configure a Second Generation Cloud SQL For MySQL instance for high 
availability by following this guideline 
<https://cloud.google.com/sql/docs/mysql/configure-ha>. 

For any supported language of your interest, you may follow the respective 
quickstart 
<https://cloud.google.com/appengine/docs/standard/python/quickstart> to get 
familiar with how to create a small App Engine application. 

For your last question, I should note that you can connect to your on 
premises databases 
<https://cloud.google.com/appengine/docs/standard/python/using-third-party-databases#on_premises>
 
which exist outside Google Cloud from App Engine as well.

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