The "failed_to_connect_to_backend" is similar to "failed_to_pick_backend" 
response and this often occurs when the load balancer knows where it wants 
to send traffic but cannot successfully route its request or find a healthy 
or available instance. Reviewing the instance usage and health checks 
<https://cloud.google.com/load-balancing/docs/https/#http_load_balancing>, 
might be appropriate to ensure these responses are correlated. 

This error message may also be returned whenever there are a low number of 
instances serving your service 
<https://issuetracker.google.com/71840041#comment25>. For example, this 
error may be returned whenever an unexpected spikes in traffic occur and 
there are not enough instances to handle the received requests. In this 
type of situations, the load balancer attempts to route your application 
requests but it does not have instances to serve those request, hence, it 
will produce this "failed_to_connect_to_backend" or 
'failed_to_pick_backend' error. 

Perhaps you can add a screenshot of your app.yaml file of your AppEngine 
application, this should display the configurations that apply to your 
instance presently, and of course, the number of instances you configured.

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