On Monday 19 June 2006 10:51, Cedric Meyerowitz wrote:
> For the past 5-10 years the NPS told us that 1st line treatment for
> Hypertension in Australia is Diuretics / Betablockers.  Evidence based
> medicine moved away from that many years ago.  Finally in the last 3 months
> the NPS has discovered that they the NPS was wrong.  Yet they now want to
> develop this software.  I haven't yet seen the NPS's views on treating
> cholesterol in diabetics.  PBS won't subsidise treatment at the levels the
> DM association here & overseas advocates.  If NPS want to become more
> credible, they should be vocal on this topic.

I am not aware that the NPS stated that it was wrong. Can you please point me 
to some reference?

For all I know (I am not afiliated with the NPS in any way) the NPS sifts 
through the available evidence from an unbiased academic perspective, and 
makes recommendations based on that evidence. Recommendations btw which you 
can take or leave, nobody forces you to adhere to them. Recommendations btw 
which only have some limited degree of influence on PBS listsings

Most doctors are taken for suckers by biased publications most if not all of 
the time. Pharmaceutical companies have been demonstrated to suppress 
unfavourable study results, to manufature results by statistical tweaking 
maneuvres etc., their reps are trained on how to give their sales spiel 
without triggering any critical thoughts and so forth.

So we need some balance in this game. somebody who has the *long term* 
interest of the patient at heart from a neutral perspective, and you will 
certainly understand that keeping a public health system financially viable 
is definitely in any patient's vital interest.

I still can't see any convincing evidence why I should not chose a low dose 
Thiazide as a first line drug in essential hypertension in people with no 
other risk factors / concomittant diseases that would make me decide in 
favour of for example an ACEI.  

Can you? If so, please point me to the references. and mind you, I am not 
intersted in barely statistically significant reductions of 
some-endpoint-or-other - what I am interested in is seeing the impact on long 
term overall mortality and morbidity. Anything else is interesting from a 
theoretical point, but meaningless to the patient I prescribe the medication 
for.

All that said, what we *REALLY* would need is a government that pulls the 
finger out and does the studies we really want to see - hed-to-head studies 
with overall mortality and morbidity as endpoints, with long term follow up, 
and merciless publication of the results regardless ofwhether it suits one 
particular party or not.

Horst
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