I'd be interested in people's comments on this report?
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Heart meds: half patients don't comply

http://www.pharmainfocus.com.au/news.asp?newsid=1732

Posted 28 May 2007

A vast problem with cardiovascular medicines compliance in Australia has
been confirmed by the latest research from the Australian Institute of
Health and Welfare (AIHW).

A report released last week, "Medicines for cardiovascular health: are
they used appropriately?" examines how medicines for cholesterol
reduction, hypertension and ischaemic heart disease are being prescribed
by GPs and used by patients.

Susana Senes of the Institute's Cardiovascular Disease and Diabetes
Unit, said 10% to 25% of patients had discontinued their medicines six
months after starting treatment, and this rose to 21% to 47% 24 months
after first being prescribed medication.

"Overall, the results of our study indicate a high level of
discontinuation of medicines that are generally intended to be taken
long-term. This represents a significant waste of resources and a lost
opportunity to prevent cardiovascular disease with medicines known to be
effective," the study report said.

The statistical study was based on BEACH data from 2000 to 2006 and
found that persistence - continuing to take prescribed medications - and
compliance - taking them at the correct frequency and dose - both
declined after patients were initially prescribed.

In particular it revealed that one in six patients (17%) had
discontinued statins at six months from the start of therapy. This
figure exceeded one in three after 24 months (35%). "In the first 12
months of therapy, 77% of newly prescribed patients were assessed as
compliant with statins, that is, they had sufficient medicine to use it
at the prescribed frequency and dose," the report said.

The picture was somewhat better for angiotensin II receptor antagonists
and ACE inhibitors with 88–91% of patients persisting with treatment
after six months. After 24 months 75–79% were still taking the
medicines. The higher figures were for combination products.

Eighty-seven percent of newly prescribed patients were assessed as
compliant with ACE inhibitors or plain angiotensin II antagonists, and
89% were compliant with angiotensin II antagonists combinations.

Three quarters of beta-blocker patients continued filling their
prescriptions at six months but by 24 months this had dropped to almost
half.

The same survey found that over 365,000 patients only ever received one
script for a cardiovascular medication resulting, it said, in a minimum
cost to government and patients of $7.4 million which was effectively
wasted.

Although the AIHW said it did not have access to patient information
that would allow it to explore why patients were stopping their
medications, "The fact that for the most part our analyses were confined
to concessional patients, for whom out-of-pocket expenses on medicines
would be relatively low, suggests that cost does not play a big role".

It quoted other research showing that factors associated with poor
concordance (persistence and compliance) include the treatment of a
condition with no symptoms (such as high blood pressure and high blood
cholesterol), the presence of depression, inadequate follow-up or
discharge planning, side effects, poor communication between health
professional and patient, patient’s lack of understanding of their
condition, patient’s lack of belief in the benefit of treatment,
complexity of treatment, missing doctor’s appointments and cost.
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