Have you had a look at

to see if that technique would be applicable to you and look through
the references given?  When you do absolute transformations you will
need to think about standard state (and standard volume).

On Thu, 13 Oct 2016 15:33:47 +0200
Alex <alexanderwie...@gmail.com> wrote:

> Dear gromacs user,
> As you know the binding free energy is the difference between the free
> energy change inbounded state and unbounded state.
> \Delta (\Delta G)_(binding) = \Delta G_(bounded)  - \Delta
> G_(unbounded).
> Then my question is that if it is necessary to simulate the free
> energy change of bonded and unbounded states in the identical volume
> size?
> In another meaning if the free energy change (either bounded or
> unbounded) is a volume depended quantity?
> I am using FEP method to calculate the binding free energy of amino
> acid to  a solid surface.
> Best regards,
> Alex

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