Unfortunately, no. For running grpc-dotnet, you need to be on the ASP.NET 
Core stack, i.e. on .NET Core 3+ (or even .NET Core 2+ has just went out of 
support a few days ago).
As described in https://grpc.io/blog/grpc-csharp-future/, once Grpc.Core is 
deprecated, all the users will be expected to migrate to grpc-dotnet.
Realistically, the Grpc.Core package will remain available for quite a 
while after that (we're not going to actively hide/remove it), but it won't 
be getting official support past the deprecation date.

Can .NET 5 and .NET 6 (where grpc-dotnet is fully supported) help you with 
migrating off of .NET Framework?
Btw, if this is about the needing to run on older windows versions (that 
don't have .NET Core or .NET 5+, preinstalled), please note that with .NET 
5+ you can build standalone single-file deployments, which remove the need 
to pre-install stuff on machines where you're are deploying.

On Wednesday, August 11, 2021 at 2:55:26 PM UTC+2 Tom Teag wrote:

> It was announced that the Grpc.Core package will be phased out. Is there 
> any other possibility to run a gRPC Server on the full .NET Framework (4.8) 
> than using the Grpc.Core package?

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