There is a basic setup for the Gtk Application in Python here

https://developer.gnome.org/gnome-devel-demos/stable/hello-world.py.html.en

For C you can check 

https://github.com/cecashon/OrderedSetVelociRaptor/blob/master/Misc/Csamples/gtk_app1.c

which has a menu but doesn't use builder with an application. Maybe partial 
help.

Eric

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