I don't know if there are any known issues.
I can only give my experience. My database has reached 125GB size with 
1.3.173. The performance is ok for my usage. 

Anyhow this is not a general statement. You have to test yourself if the 
performance is ok for your application. 
I can recommend to use a SSD instead of a harddisk to store the database 
files. 

Uli

On Wednesday, September 18, 2013 10:08:29 AM UTC+2, Federico Dal Castello 
wrote:
>
> Should I suppose that there are no known performance issues on large 
> databases? Has anyone experienced such kind of issues now or in the past?
>
> Thank you
> Federico
>

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