Personally I would run 4 Cat 5e and 2 RG6 runs to each room in the house. I did this back in 2000 (using Cat 5 instead) and never regretted it. You only want to run cable infrastructure once so plan for as big as you can possibly imagine. My thinking was that in the future I might want more than one machine in a room (maybe a home office or home theater) so I put multiple drops in each room. And the RG6 is useful for routing video around if you want to do the whole house A/V route.
Yes, wireless is much easier but IMHO I can't stand the crappy speed. Especially for serving video, transferring files, and broadband downloads. And anyone who wants can pretty much tap into your wireless. And you don't run into those weird loss of signal/low signal problems with wired connections. Just my $0.02. -- Brian
