Hi folks,

We're about to start MRI data collection on a NIDA-funded project in which each 
participant will undergo 9 separate fMRI sessions.  We'd like to use our HCP MR 
sequences for this project, as we've done for several other current studies.  
But the multi-session design of this one brings up a question that I need some 
guidance on.

>From what I recall, the T1 and T2 is used to create a bias field that is then 
>registered to the fMRI data and used in the final intensity normalization step 
>in the fMRIVolume processing procedures, right?  So if we DON'T collect a 
>brand new T1 and T2 at each and every one of these 9 sessions, but instead 
>refer the HCP scripts back to a T1 and T2 from collected at a baseline scan, 
>will we be messing up something crucial and unfixable?  Our study design is 
>such that 3 of these MRI sessions happen each day... The packed protocol 
>follows a highly rigid and moment-by-moment schedule, so that we unfortunately 
>can't add an extra 15-16 minutes 3x a day for new T1/T2s each session and 
>still get everything else done.  If we can collect the structural data only 
>once at the beginning, we can use HCP sequences and processing on this project.

Just want to make sure I fully understand the issues and consequences, whether 
they be large or teeny...

Thanks,
Mike


Michael C. Stevens, Ph.D.
Director, Clinical Neuroscience & Development Laboratory, Olin Neuropsychiatry 
Research Center
Director, Child & Adolescent Research, The Institute of Living / Hartford 
Hospital
Adjunct Associate Professor of Psychiatry, Yale University School of Medicine



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