Dear HCP experts,

I would like to analyze some HCP diffusion data. I am using the
preprocessed HCP data from the 900 subjects release.

I would like to do dtifit and run bedpostx and then tractography (I know
dtifit is unrelated to the latter bt I'm mentioning it because I would like
to be consistent in my analysis).

Two questions:

a) I found this dtifit command in the HCP mail list archives:

dtifit -k data.nii.gz -r bvecs -b bvals -m nodif_brain_mask.nii.gz -o >>>
> $OUTDIR/$SUBJECT/dti --gradnonlin=grad_dev.nii.gz
>

But also I found this code for voxel-wise correction of dMRI gradients:

>
> https://www.humanconnectome.org/storage/app/media/documentation/data_release/Q1_Release_Appendix_II.pdf
>

*When I run the dtifit command above do I use the new_bvals and new_bvecs?*

Hence do I run:

> dtifit -k data.nii.gz -r new_bvecs -b new_bvals -m nodif_brain_mask.nii.gz
> -o >>> $OUTDIR/$SUBJECT/dti --gradnonlin=grad_dev.nii.gz
>

or does the "--gradnonlin=grad_dev.nii.gz" in the command does the same job
as the code I found in the Q1_Release_Appendix_II.pdf?

b) *When I run bedpostx_gpu do I need to use the new_bvals* in a script
like this:
bedpostx_gpu T1w/Diffusion -n 3 -b 3000 -model 3 -g —rician

Thank you.

Best,
*Athanasia Metoki*
Psychology Doctoral Student - Brain and Cognitive Sciences Program
Cognitive Neuroscience Laboratory
Temple University
Department of Psychology
1701 N 13th St.
Philadelphia, PA 19122
Email: [email protected]

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