I'd go with "A", but it really depends on what you are going to do with the 
sections after fixation.

In the protocol for Oil Red O in Freida's second edition (that I use almost 
daily combined with some steps from PolyScientific's ORO protocol), step #1 
says to fix in 40% formaldehyde. Doesn't say vapors so I plunk the slides in 
the liquid 40%.
I have fixed frozen sections for regular H&E and other stains as well in 40% 
formaldehyde and they come out beautiful.
Unless there is some specific request or reason to use cold acetone or alcohol 
this is what I use.

Andrea Grantham, HT (ASCP)
Senior Research Specialist
University of Arizona
Cellular and Molecular Medicine
Histology Service Laboratory
P.O.Box 245044
Tucson, AZ 85724

[email protected]<mailto:[email protected]>
Tel: 520.626.4415     Fax: 520.626.2097





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