>can z/OS support 80 x 32 = 2560 active CPs per sysplex?

No sysplex cares how many CPs an individual system has.

If a single z/OS system can have n CPs, and if you can have m of those in 
a sysplex then by definition you can have n*m CPs in a sysplex.
The n*m number is basically "content free" -- it is likely not a useful 
indication.

>how bad was the overhead incurred in 
>managing an 80-way z/OS?

I do not have that information. If and when it is relevant to provide that 
information, I'm sure it will happen. As with any MP situation, it is 
extremely workload-sensitive. If your 80-way is primarily doing 80 unique 
things you get one sort of answer. If it ist primarily running 80 tasks of 
the same server all contending (for example) for a particular lock or ENQ 
or even a 256-byte line of memory) you get another very different answer.

Peter Relson
z/OS Core Technology Design

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