Hi Christopher - Image these sizes are certainly not apropriate to be dealt with straight from Python code on a pixel by pixel basis.
I once implementd a Tiff reader in C using libtiff, and it was not hard to do - maybe you should try and move part of your processing to C , and implement some Python itnerface that would allow you to drive everything with simpler scripting. (For example, you could have a libtiff C function that would create you an Y-Z slice of your data, and return that as a 2d array to python) I don't know the hdf5 tables or H5Py Dr. barker mentioned above, but if you feel like purisuing the C-libtiff with python bindings line, feel free to contact me. js -><-
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