I am increasingly seeing these messages in my log files...
 
Currently see about a dozen per day.  For the most part these are POP3 accounts and the message seems to get delivered on a retry.  Today however we had an IMAP user receive one of these messages at the same time their entire main.mbx disappeared.  Imail must have created a new main.mbx and kept chugging along, but a couple of hundred email mesasges in that account were nowhere to be found (except on backup).
 
My question is why is this error being generated in the first place, and when it is is the whole mailbox always being regenerated?  With our usage pattern on the POP3 accounts it is possible that that is happening and we never noticed - it may have taken the IMAP account to make it noticed this time.
 
We have no active virus scanning on the mail server (except fprot thru declude) or any other processes running that would be accessing the mailbox files other than Imail (Version 8.22 btw, on windows server 2003)
 
Any Ideas or solutions.
 
Here is a snippet of the log with domain and user changed to "changed"
-------------------------------------------------------------------------------------------------------
 
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) ERR changed.com read open fail (E:\IMail\changed_com\Users\changed\main.mbx)
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) ERR local fail to  changed.com changed-main (310) 
user@domain.com 0
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) Creating message from Postmaster
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) Delivery process now using new file: ed7c00000cf086b9
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) requeuing E:\IMail\spool\qed6801cd0000ffd5.smd R0 T0
20061023 122740 127.0.0.1       SMTP (ed6801cd0000ffd5) finished E:\IMail\spool\qed6801cd0000ffd5.smd status=3

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