I've noticed I have the majority of my emails in my queue awaiting resend.
That is good. If there are lots of E-mails there that aren't awaiting re-tries, it often means that there is a problem (E-mails can't be delivered fast enough, lots of orphaned E-mails, etc.).
I have my queue manager retry timer set at 30 minutes, and my SMTP set to send messages 20 tries before returning to sender. This seems a bit excessive, what are yours set at?
The old recommendation used to be to re-try for up to 48 hours. I would recommend a minimum to be the amount of time that a mailserver may legitimately be down without someone to get it back online. For ISPs, that's usually a very short time period (even in the middle of the night, someone could be paged to get it back online). But if you receive E-mail from small businesses that run their own mailservers, there's a decent chance that someone could go wrong overnight that would cause it to be down for as much as about 16 hours. So I would recommend a minimum of 16 hours. Yours, though, is only 10 hours. So I would recommend switching to 32 tries.
However, feel free to reduce the retries on bounces ("Null sender maximum tries"), as those are normally where the bogus E-mails are (for example, spam sent to addresses with "vacation" messages). If it is too low, the worst that happens is someone doesn't get a bounce message.
-Scott
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