> have anyone successfully used Cyrus in ISP/webhosting environment?
> This means many different domains with little number of mailboxes per
> domain.
> Number of mailboxes: 500K - 1M
> Disk space used: 1TB and more
> Number of messages (daily number): 2-3M and more
> Is it recommended to use Cyrus in such environment?

FastMail does.

http://www.fastmail.fm

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