Feature Requests item #855049, was opened at 2003-12-05 13:24
Message generated for change (Tracker Item Submitted) made by Item Submitter
You can respond by visiting: 
https://sourceforge.net/tracker/?func=detail&atid=379136&aid=855049&group_id=23629

Category: None
Group: None
Status: Open
Priority: 5
Submitted By: Nobody/Anonymous (nobody)
Assigned to: Nobody/Anonymous (nobody)
Summary: a way to detect distance from surface

Initial Comment:
Rasmol has predefined selection parameter of amino 
acids called surface and one called buried.  Since so 
much relies on interaction at surfaces it would be nice if 
JMOL could select actual surface residues and buried 
residues.

Another reason for such a request - I was looking at this 
paper below and naively thought it might be easy to use 
Chime to color/list residues based on atom depth. (It is 
especially interesting since in general more conserved 
residues usually tend to be solvent inaccessible.) I tried 
to come up with a script that would start color coding 
based on atom depth but realized the problem was that 
after I had calculated the water accessible surface area 
I couldn't figure out the command to select residues 
within a certain distance from the calculated surface. I 
looked at MDL's info on surface stuff but couldn't figure 
it out. 
Anyway it would be nice to think about for building into 
Jmol since in the building process.  A lot of drug design 
and examination of interactions depends on surfaces.
Here is the paper:
Atom depth in protein structure and function 
Alessandro Pintar, Oliviero Carugo and Sandor Pongor 
Atom depth, originally defined as the distance between a 
protein 
atom and the nearest water molecule surrounding a 
protein, is a 
simple but valuable geometrical descriptor of the protein 
interior. 
<http://reviews.bmn.com/journals/atoz/latest?
pii=S0968000403002287&node=TOC%40%40TIBS%
40028%4011%40028_11>


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