[EMAIL PROTECTED] wrote:

>
>I suggested to generalize to deal with situations when the isotope number is 
>specified in the SMILES string *and* in the molecule. I never thought about 
>the situation where the molecule doesn't specify isotope number but the SMILES 
>string do.
>
>I don't know what is the best in this situation (my preference to 1):
>1. considering that unspecified isotope matches all isotopes in Smiles
>2. considering that unspecified isotope matches no isotopes in Smiles
>3. considering that unspecified isotope matches only "natural" isotope in 
>Smiles. But to have a coherent behaviour, we need to define all "natural" 
>isotopes.
>
>  
>
The more I think about it, the more I think we have to do whatever 
Daylight says we do. They must have thought about this. Do you want to 
ask them about isotopes? My understanding -- maybe a place to start -- 
is to ask if the following is correct:

[C] matches any isotope of carbon, explicitly indicated or not.
[12C] matches only explicitly labeled carbon-12.

Bob


>  
>
>>So OK if I leave the check in, as it was for hydrogen, but generalized, 
>>but not part of SmilesParser?
>>    
>>
>
>You can modify the PatternMatcher to deal with natural/unnatural isotopes, but 
>I think that this notion should not be in the SmilesParser.
>
>The SmilesParser should just parse Smiles strings without interpreting them 
>more than the specification of the Smiles format.
>
>Nico
>
>
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