Bob Hanson wrote:

> that's next. I have an idea but no time to work on it. It would involve 
> the MOL2 format bond stereochemistry designations.

I can't find anything about stereochemistry in the MOL2 specs, but 
MOL has "up", "down", "none" and "nonspecified" bond types (and 
JChemPaint exports the first 3 into MOL).

> Try at least setting Z values differently for the different atoms. Are 
> all the H atoms there? It will help a lot if the H atoms are on the 
> carbons that might otherwise invert.

I've tested applying this:

bondType = 1 (up)  ==>  Z= 1
bondType = 6 (down)  ==>  Z= -1
all the others have Z=0

and although not infallible, it does improve stereo retention during 
minimization.


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