The ability to run  Jmol using local data is useful for testing (and in my case 
from giving demos/talks from the laptop).  Finding out how to allow this is 
getting more fun with each release of both Java and  the  OS; I here offer my 
recipe for OS X Mavericks:

1. Open a local file using Safari (a file which say invokes the  Jmol applet)
2. In Safari/Preferences/Security/Internet plug-ins,   check allow, and then 
manage  Website settings
3.  Select Java as the plug-in, and "currently open website" should declare 
“Local documents”.  You should select  "Allow always".  If you do not have a 
local document open at the time, this option will not appear.

This should do the trick and allow Jmol to open up in local mode.  I would 
mention that these various policies depend very much on the  browser being 
used.  Thus  Firefox is different (and Chrome, being 32-bit, does not run  
64-bit Java applets). 

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