Same problem here. Lenovo Ideapad Flex 10. Came with windows 8 installed and 
updated to windows 10. Had Ubuntu 14.04 installed as dual boot and had each 
release of Ubuntu updated since 14.04.
I was dual booting using legacy for Ubuntu and UEFI for occasional access to 
windows 10. Only recent change has been upgrade to version 17.10. I can no 
longer save changes to the boot order in the BIOS. I cannot therefore boot from 
USB and am not able to boot into windows.
We need an explanation of what has has happened during the upgrade and whether 
or not there is a viable solution or workaround.
The trigger for this problem arising was clearly the upgrade from 17.04 to 
17.10. Given that, my expectation is that Canonical will take responsibility 
for finding the root cause and giving us some alternative solutions / 
workarounds.

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You received this bug notification because you are a member of Kernel
Packages, which is subscribed to linux in Ubuntu.
https://bugs.launchpad.net/bugs/1734147

Title:
  Ubuntu 17.10 corrupting BIOS - many LENOVO laptops models

Status in linux package in Ubuntu:
  Confirmed
Status in linux source package in Artful:
  Confirmed

Bug description:
  Hi all,

  Basically on Lenovo Y50-70 after installing Ubuntu 17.10, many users
  reported a corrupted BIOS.

  It's not possible to save new settings in BIOS anymore and after
  rebooting, the system starts with the old settings.

  Moreover (and most important) USB booting is not possible anymore
  since USB is not recognized. It's very serious, since our machines do
  not have a CDROM.

  Lenovo forums at the moment are full of topics regading this issue.

  Thank you!!

  #### UPDATE (01/12/2017) ####

  LENOVO machines affected so far (please add your affected model to
  this list):

  Lenovo Y50-70
  Lenovo G40-30
  Lenovo U31-70
  Lenovo G50-70
  Lenovo Z50-70
  Lenovo Yoga Thinkpad (20C0)
  Lenovo G50-80
  Lenovo S20-30
  Lenovo Yoga 2 11" - 20332
  Lenovo B40-70

  ---

  Temporary workaround:
  https://forums.lenovo.com/t5/Lenovo-P-Y-and-Z-series/Y50-70-BIOS-Can-t
  -Save-Settings-Or-Exit/m-p/3853208#M157885

  ---

  result from apport-collect 1734147:

  ---

  ApportVersion: 2.20.7-0ubuntu3.5
  Architecture: amd64
  AudioDevicesInUse:
   USER        PID ACCESS COMMAND
   /dev/snd/controlC1:  tob        1608 F.... pulseaudio
   /dev/snd/controlC0:  tob        1608 F.... pulseaudio
  CurrentDesktop: ubuntu:GNOME
  DistroRelease: Ubuntu 17.10
  InstallationDate: Installed on 2017-10-22 (37 days ago)
  InstallationMedia: Ubuntu 17.10 "Artful Aardvark" - Release amd64 (20171018)
  MachineType: LENOVO 20378
  Package: linux (not installed)
  ProcFB: 0 inteldrmfb
  ProcKernelCmdLine: BOOT_IMAGE=/boot/vmlinuz-4.13.0-17-generic 
root=UUID=7def04d3-7336-44b2-a084-2415f9dc2328 ro quiet splash vt.handoff=7
  ProcVersionSignature: Ubuntu 4.13.0-17.20-generic 4.13.8
  RelatedPackageVersions:
   linux-restricted-modules-4.13.0-17-generic N/A
   linux-backports-modules-4.13.0-17-generic  N/A
   linux-firmware                             1.169
  Tags:  artful wayland-session
  Uname: Linux 4.13.0-17-generic x86_64
  UpgradeStatus: No upgrade log present (probably fresh install)
  UserGroups: adm cdrom dip lpadmin plugdev sambashare sudo
  _MarkForUpload: True
  dmi.bios.date: 08/12/2015
  dmi.bios.vendor: LENOVO
  dmi.bios.version: 9ECN43WW(V3.03)
  dmi.board.asset.tag: No Asset Tag
  dmi.board.name: Lenovo Y50-70
  dmi.board.vendor: LENOVO
  dmi.board.version: 00000000Not Defined
  dmi.chassis.asset.tag: No Asset Tag
  dmi.chassis.type: 10
  dmi.chassis.vendor: LENOVO
  dmi.chassis.version: Lenovo Y50-70
  dmi.modalias: 
dmi:bvnLENOVO:bvr9ECN43WW(V3.03):bd08/12/2015:svnLENOVO:pn20378:pvrLenovoY50-70:rvnLENOVO:rnLenovoY50-70:rvr00000000NotDefined:cvnLENOVO:ct10:cvrLenovoY50-70:
  dmi.product.family: IDEAPAD
  dmi.product.name: 20378
  dmi.product.version: Lenovo Y50-70
  dmi.sys.vendor: LENOVO

  ---

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