In acprep there is currently a test for detecting MacPorts and installing appropriate dependencies. In my (one-time) experience with Homebrew just now, you can add a similar section for Homebrew easily:
Look for /usr/local/bin/brew. brew install cmake boost gmp mpfr I expected to need a lot more dependencies, but I guess they're preexisting. This was on OS X Lion with Xcode 4.3. Matthew
