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Today's Topics:
1. 'Chinese media warns that the rise of nationalistic "fandom
culture" in scientific discussions could harm innovation.'
(Stephen Loosley)
2. Next-generation sequencing: "A robust and rapid response to
the next viral pandemic." (Stephen Loosley)
----------------------------------------------------------------------
Message: 1
Date: Sun, 17 Nov 2024 16:31:07 +1030
From: Stephen Loosley <[email protected]>
To: "link" <[email protected]>
Subject: [LINK] 'Chinese media warns that the rise of nationalistic
"fandom culture" in scientific discussions could harm innovation.'
Message-ID: <[email protected]>
Content-Type: text/plain; charset="UTF-8"
Copy of contributions to:
https://www.reddit.com/r/technology/comments/1gsje1g/nationalistic_chinese_bloggers_warned_over_costs/
Regarding:
https://www.scmp.com/news/china/science/article/3286815/nationalistic-chinese-bloggers-warned-over-costs-shouting-down-scientists
Comments Section
TheSleepingPoet
? 11h ago
? Chinese scientists are facing online backlash, accused of being
?pro-American? for pointing out deficiencies in the country?s primary research
and technology ecosystem. State-affiliated media warn that the rise of
nationalistic "fandom culture" in scientific discussions could harm reputations
and impede innovation. Physicist He Zuoxiu and others have cautioned that
neglecting these issues could hinder China?s technological advancement.
Upvote
59
Tailcracker
? 6h ago
? It's ironic calling the scientists Pro American when it's the nationalistic
fandom culture that actually emulates America. America is a place where
nationalists also insert themselves into scientific discussions and spread
misinformation which harms reputations and impedes innovation.
Upvote
25
MorselMortal : Profile Badge for the Achievement Top 10% Commenter Top 10%
Commenter
? 2h ago
? Yeah, it's very similar to Trumpism, just relabelled and redigested for the
Chinese.
Upvote
5
Nelson56
? 55m ago
? Something tells me there will be lots of examples of this exact phenomenon
over the next four years
Upvote
2
Tazling Profile Badge for the Achievement Top 10% Commenter Top 10% Commenter
? 10h ago
? if the coming era is post democratic and we most live under repressive
authoritarian rule, I'd rather have sane authoritarians who actually pursue the
national interest than a mob of oligarch looters and superstition peddlers.
China for the W. they own the next century thanks to being reality based. not
nice, not good, not kind, but reality based and 98+ percent literate.
Upvote
7
MorselMortal Profile Badge for the Achievement Top 10% Commenter Top 10%
Commenter
? 2h ago
? Mostly because their leaders are engineers and scientists, instead of
lawyers and businessmen. Sure, they have those two, but they've got a lot more
STEM in there.
Upvote
2
Spiritual_Tennis_641
? 7h ago
? Yup and biggest population with the soon To be best army in the world. Rather
than our a** backwards democracy fighting over the stupidest stuff imaginable
while investing in nothing that generates future wealth or innovation.
---
------------------------------
Message: 2
Date: Sun, 17 Nov 2024 18:14:42 +1030
From: Stephen Loosley <[email protected]>
To: "link" <[email protected]>
Subject: [LINK] Next-generation sequencing: "A robust and rapid
response to the next viral pandemic."
Message-ID: <[email protected]>
Content-Type: text/plain; charset="UTF-8"
"Our assay, which was granted breakthrough device designation from the US Food
and Drug Administration (FDA) in August of 2023, demonstrates the feasibility
of routine mNGS testing in clinical and public health laboratories, thus
facilitating a robust and rapid response to the next viral pandemic."
Laboratory validation of a clinical metagenomic next-generation sequencing
assay for respiratory virus detection and discovery
Download PDF Article Open access: Published: 12 November 2024
https://www.nature.com/articles/s41467-024-51470-y
Laboratory validation of a clinical metagenomic next-generation sequencing
assay for respiratory virus detection and discovery
Jessica Karielle Tan, Venice Servellita, Doug Stryke, Emily Kelly, Jessica
Streithorst, Nanami Sumimoto, Abiodun Foresythe, Hee Jae Huh, Jenny Nguyen,
Miriam Oseguera, Noah Brazer, Jack Tang, Danielle Ingebrigtsen, Becky Fung,
Helen Reyes, Melissa Hillberg, Alice Chen, Hugo Guevara, Shigeo Yagi, Christina
Morales, Debra A. Wadford, Peter M. Mourani, Charles R. Langelier, Mikael de
Lorenzi-Tognon, ?Charles Y. Chiu Show authors Nature Communications volume 15,
Article number: 9016 (2024) Cite this article
2589 Accesses
114 Altmetric
Abstract
Tools for rapid identification of novel and/or emerging viruses are urgently
needed for clinical diagnosis of unexplained infections and pandemic
preparedness.
Here we developed and clinically validated a largely automated metagenomic
next-generation sequencing (mNGS) assay for agnostic detection of respiratory
viral pathogens from upper respiratory swab and bronchoalveolar lavage samples
in <24?h.
The mNGS assay achieved mean limits of detection of 543 copies/mL, viral load
quantification with 100% linearity, and 93.6% sensitivity, 93.8% specificity,
and 93.7% accuracy compared to gold-standard clinical multiplex RT-PCR testing.
Performance increased to 97.9% overall predictive agreement after discrepancy
testing and clinical adjudication, which was superior to that of RT-PCR (95.0%
agreement).
To enable discovery of novel, sequence-divergent human viruses with pandemic
potential, de novo assembly and translated nucleotide algorithms were
incorporated into the automated SURPI+ computational pipeline used by the mNGS
assay for pathogen detection.
Using in silico analysis, we showed that after removal of all human viral
sequences from the reference database, 70 (100%) of 70 representative human
viral pathogens could still be identified based on homology to related animal
or plant viruses.
Our assay, which was granted breakthrough device designation from the US Food
and Drug Administration (FDA) in August of 2023, demonstrates the feasibility
of routine mNGS testing in clinical and public health laboratories, thus
facilitating a robust and rapid response to the next viral pandemic.
--
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