Taiwan scientists find antibody that fights coronavirus

Taiwanese researchers discover antibody that inhibits coronavirus by up to 98%

By Keoni Everington, Taiwan News, Staff Writer  2020/05/28 15:23
https://www.taiwannews.com.tw/en/news/3941083


TAIPEI (Taiwan News) — A team of scientists at Taiwan's Chang Gung University 
(CGU) has found a monoclonal antibody (mAb) that can inhibit the Wuhan 
coronavirus (COVID-19) by over 90 percent.

The team spent several months searching for the antibody, which has the ability 
to inhibit the virus by 90 to 98 percent. In addition, it has been found to be 
effective against all four main virus strains.

In early April, researchers from CGU and Academia Sinica, the National Defense 
Medical Center, and Oxford University announced that they had identified 25 
strains of mAbs in three patients infected with COVID-19.

At the same time, they had already identified one of which could potentially 
inhibit the virus from entering the body, paving the way for medication.

Shih Shin-ru (施信如), director of the CGU Research Center for Emerging Viral 
Infections confirmed on Thursday (May 28) that through experiments there, the 
antibody has the ability to block the virus from entering the human body, with 
the ability to inhibit the virus ranging between 90 to 98 percent, reported CNA.

Moreover, the antibody had the same neutralization effect on the Wuhan, 
American, European, and Egyptian strains of COVID-19, making it an ideal 
candidate for therapeutic drugs.

Shih said that unlike pharmaceuticals, which can be toxic and produce side 
effects, antibodies are made from substances that naturally occur in the human 
body. Therefore, they are not only safe but also highly specialized, enabling 
them to identify specific viruses and inhibit or eliminate them and will not 
affect normal healthy cells in the process, while reducing the occurrence of 
side effects.

The director added that now that the CGU team has identified a suitable mAb, 
they will start a technology transfer to the private sector in June, carry out 
further tests, and ramp-up to mass production. If all goes well, the antibody 
could be commercially available by as soon as the end of the year, said Shih.

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