> I'm particularly interested in finding out whether it's necessary to 
> buy commercial communication packages for such uses, or whether it 
> can all be done just as well through astute configuration of lists 
> under a program such as Majordomo, plus a bit of employee training.
Do you known the free (GPL) software named sympa ? It allow very large
lists and a lot of configuration. One of them allows to create distribution
list using an external database : sympa can contact you compagny database
server and dynamically extract email of a category of employee.

Sympa include a web interface for list administration and list subscribers
including list archive with access control etc etc.

http://listes.cru.fr/sympa

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