Yes, there is a keyboard shorcut available for this function. If I remember 
correctly, the shorcut key was available by default in versions of OSX through 
Snow Leopard, but it has been disabled by default since then. Here are the 
steps to re-enable it.

1. Go to System Preferences > Keyboard > Shortcuts.
2. Interact with the Shorcuts Category Table.
3. Arrow down to “Accessibility.”
4. Press VO+J to jump to the Accessibility Shorcuts table.
5. Arrow down to “Invert Colors.”
6. Make sure the checkbox for this row is checked. It is unchecked by default 
in recent OSX versions.
7. You also might want to change the default shortcut key assigned to this 
function. If I recall correctly, the default shortcut key combination did not 
work if VoiceOver was in use. I changed the default shortcut key combo on my 
system to Command+Option+Shift+8, which works fine throughout my system and 
does not seem to interfere with other shortcut keys.

HTH,
Bryan


On Jun 11, 2014, at 12:13 PM, Eleanor Martha Burke 
<eleanormarthabu...@gmail.com> wrote:
> Hi All, I am wondering if I can have a hot key, or an Apple script for the 
> above, to reverse colours as a toggle like I have on my iPad Mini and iPhone. 

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