AFAIK, yes. Running MacPorts, Fink or Homebrew alongside is asking for trouble. 
Some ports won't build and other strangeness will occur.

Dom

Am 06.12.2011 um 18:50 schrieb Skip Lentz <[email protected]>:

> I already have homebrew, but I would like to use MacPorts as well for the 
> ports it has to offer that homebrew doesn't have. Will there be anything 
> going wrong with my system if I run those along with each other? Homebrew is 
> on my system in /usr/local/.
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