Kevin,

I have a Macbook Pro with 4Gb of ram and a 500Gb hd. I generally end up 
bouncing the box every three days or so. Since I work from home three days a 
week I will leave the machine up during the day and just put it to sleep at 
night. I can't recall that I have left it without a reboot for more than a 
week, but perhaps I will give this a try and see if I experience the same issue.
On Aug 18, 2010, at 8:13 PM, Kevin Shaw wrote:

> I believe this is an issue with all applications in general. I tend to find 
> that Safari, iTunes and Mail can become a bit sluggish, as well as Voiceover. 
> This is on a Macbook Pro that gets put to sleep more often than it gets shut 
> down or restarted. A quick restart often fixes the problem. 
> 
> Having said this, take into consideration that times between restarts are 
> very long—possibly a week or two—and that my MBP is running on 8 GB of RAM 
> with a 256 GB HD.
> 
> Kevin
> 
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