New paper by Nymo and co-workers on "Brucella pinnipedialis hooded seal (Cystophora cristata) strain in the mouse model with concurrent exposure to PCB 153".
Abstract Brucellosis, a worldwide zoonosis, is linked to reproductive problems in primary hosts. A high proportion of Brucella-positive hooded seals (Cystophora cristata) have been detected in the declined Northeast Atlantic stock. High concentrations of polychlorinated biphenyls (PCBs) have also been discovered in top predators in the Arctic, including the hooded seal, PCB 153 being most abundant. The aim of this study was to assess the pathogenicity of Brucella pinnipedialis hooded seal strain in the mouse model and to evaluate the outcome of Brucella spp. infection after exposure of mice to PCB 153. BALB/c mice were infected with B. pinnipedialis hooded seal strain or Brucella suis 1330, and half from each group was exposed to PCB 153 through the diet. B. pinnipedialis showed a reduced pathogenicity in the mouse model as compared to B. suis 1330. Exposure to PCB 153 affected neither the immunological parameters, nor the outcome of the infection. Altogether this indicates that it is unlikely that B. pinnipedialis contribute to the decline of hooded seals in the Northeast Atlantic. Available online: http://www.sciencedirect.com/science/article/pii/S014795711400006X# PDF request: [email protected]<mailto:[email protected]> Ingebjørg Helena Nymo, DVM PhD Post Doctoral Researcher University of Tromsø - the Arctic University of Norway Faculty of Biosciences, Fisheries and Economics Department of Arctic and Marine Biology Research Group of Arctic Infection Biology Stakkevollveien 23, N-9010 Tromsø, Norway Phone: +47 77 62 52 11 Mobile: +47 91 83 84 21 Skype: ingebjorg.helena.nymo
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