All –
We are pleased to announce a new publication regarding potassium chloride 
euthanasia of pinnipeds.  The manuscript is available open-access at: 
https://avmajournals.avma.org/doi/full/10.2460/javma.259.2.197

Whitmer, E. R., Trumbull, E. J., Harris, H. S., Whoriskey, S. T., & Field, C. 
L. (2021). Use of potassium chloride for low-residue euthanasia of anesthetized 
California sea lions (Zalophus californianus) and northern elephant seals 
(Mirounga angustirostris) with life-threatening injury or disease. Journal of 
the American Veterinary Medical Association, 259(2), 197-201.

OBJECTIVE To demonstrate the efficacy of potassium chloride (KCl) for 
low-residue euthanasia of anesthetized pinnipeds in field settings for which 
carcass retrieval for disposal is not feasible.
ANIMALS Stranded, free-ranging California sea lions (CSLs; Zalophus 
californianus; n = 17) and northern elephant seals (NESs; Mirounga 
angustirostris; 6) with lifethreatening injury or disease between May and 
August 2020.
PROCEDURES Each animal was anesthetized and then received a lethal dose of KCl 
solution administered by IV or intracardiac injection. The effective KCl dose; 
durations to cardiac arrest, respiratory arrest, and pupil dilation; and 
presence or absence of agonal breaths, muscle fasciculations, or skeletal 
movements were recorded. RESULTS Mean effective dose of KCl was 207.4 mg/kg 
(94.3 mg/lb) for the 17 CSLs and 209.1 mg/kg (95.0 mg/lb) for 5 of 6 NESs (1 
outlier NES was excluded). The range in duration from the beginning of KCl 
injection to cardiac arrest was 0 to 6 minutes, to pupil dilation was 0 to 5 
minutes, and to respiratory arrest was 0 to 5 minutes. Muscle fasciculations, 
skeletal movements, and agonal breaths were observed in both species during and 
after KCl administration.
CONCLUSIONS AND CLINICAL RELEVANCE The use of KCl provides an effective, 
low-residue method of euthanasia in anesthetized CSLs and NESs. Our recommended 
dose for these species is 250 mg KCl/kg (113.6 mg KCl/lb) delivered by 
intracardiac injection. Compared with euthanasia by barbiturate overdose, the 
use of KCl reduces the potential for secondary intoxication of scavengers and 
is appropriate in field scenarios in which the carcass cannot be retrieved for 
disposal. (J Am Vet Med Assoc 2021;259:197–201)


Emily R. Whitmer, DVM
[email protected]<mailto:[email protected]>

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