Dear Colleagues, We are glad to announce a new publication entitled "*The bottlenose dolphin (Tursiops truncatus): A novel **model for studying healthy arterial aging"*
*ABSTRACT:* Endothelial function declines with aging and independently predicts future cardiovascular disease (CVD) events. Diving also impairs endothelial function in humans. Yet, dolphins, being long-lived mammals adapted to diving, undergo repetitive cycles of tissue hypoxia-reoxygenation and disturbed shear stress without manifesting any apparent detrimental effects, as CVD is essentially nonexistent in these animals. Thus, dolphins may be a unique model of healthy arterial aging and may provide insights into strategies for clinical medicine. Emerging evidence shows that the circulating milieu (bioactive factors in the blood) is at least partially responsible for transducing reductions in age-related endothelial function. To assess if dolphins have preserved endothelial function with aging due to a protected circulating milieu, we tested if the serum (pool of the circulating milieu) of bottlenose dolphins (*Tursiops truncatus*) induces the same arterial aging phenotype as the serum of age-equivalent humans. We incubated conduit arteries from young and old mice with dolphin and human serum and measured endothelial function *ex vivo *via endothelium-dependent dilation to acetylcholine. While young arteries incubated with serum from mid-life/older adult human serum had lower endothelial function, those incubated with dolphin serum consistently maintained high endothelial function regardless the age of the donor. Thus, studying the arterial health of dolphins could lead to potential novel therapeutic strategies to improve age-related endothelial dysfunction in humans. *Link* to the full manuscript: https://journals.physiology.org/doi/abs/10.1152/ajpheart.00464.2024?journalCode=ajpheart The full manuscript will be in gold open access in the upcoming weeks. Kind regards, Yara Bernaldo de Quirós Assistant Professor Institute of Animal Health and Food Safety Universidad de las Palmas de Gran Canaria [email protected]
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