(I tried to send this in reply to Chris Goldsbury, twice, but for some reason 
it bounced back, twice.)

European colonization of the East Coast *did not wait* "until after the native 
tribes were wiped out by an unknown disease imported by trappers". It began in 
Florida, continued in Virginia and Quebec, and then proceeded into New England. 
You are probably referring to the epidemic that preceded the pilgrims landing 
at Plymouth. However, even in that case, the local population would have 
recovered from the epidemic if the great migration into Massachusetts a decade 
later had not occurred. In fact, the depopulation of the Native American 
population of the East Coast was not an accomplished fact until after the 
series of wars up and down the coast including "King Phillip's War" in New 
England and the Yamasee wars in Carolina/Georgia had been won by the European 
invaders. The diaspora of East Coast peoples and polities to the west was 
finalized by those wars, not by disease.

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