I build matplotlib 0.87.7 for Python 2.5 with support for TkAgg and 
WXAgg, the latter using the binary wxPython  2.7 installer from 
<http://pythonmac.org/packages>. Unfortunately, the matplotlib had a 
problem: WxAgg failed with:
MemoryError: _wxagg.convert_agg_to_wx_bitmap(): could not create the wx.Bitmap
Disaabling acceleration as follows seems to work around the problem, 
but I don't know how complete a fix it is:
import matplotlib.backends.backend_wxagg
matplotlib.backends.backend_wxagg._use_accelerator(False)

Christopher Barker was immensely helpful in explaining what was 
wrong. There are two issues:
1) The wxPython installer is finding the wrong wx-config. It finds 
the one for the outdated built-in wx instead of the one used by 
wxPython (which is deeply buried and very unlikely to be on your 
$PATH).
2) There are bugs in the particular wxPython 2.7 I was using that 
prevent building matplotlib. Note that 2.7.x is, by definition, a 
development branch; the next stable release series will be 2.8.x.

So the recipe that works is:
- Install wxPython 2.6.x (preferably the unicode version) from
   <http://www.wxpython.org/download-2.6.3.3.php#binaries>
or perhaps soon from:
    <http://pythonmac.org/packages/>

- Put its wx-config on your path. I did this as follows:
sudo ln -s 
/usr/local/lib/wxPython-unicode-2.6.3.3/lib/wx/config/mac-unicode-debug-2.6
I suggest removing the link when finished since it won't be updated 
if you ever update wxPython.
(Note: I found the correct file by looking for wx-config using File Buddy).

- Install one or more numeric of numpy, numarray and/or Numeric
Binary installers are available at <http://pythonmac.org/packages/>

- Build matplotlib as usual.

-- Russell

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